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T17879 |
E3 ligase Ligand 8
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Others
,
Ligand for E3 Ligase
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E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. The E3 ligase Ligand 8 can be linked to protein ligands through linkers to form PROTACs, which are inducers of ubiquitination-mediated degradation of cancer-promoti... |
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T7763 |
Thalidomide-4-OH
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Cereblon ligand 2,E3 ligase Ligand 2 |
Ligand for E3 Ligase
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Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs |
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T9809 |
E3 ligase Ligand 23
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Ligand for E3 Ligase
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E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome. |
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T7752 |
(S,R,S)-AHPC-Me
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VHL ligand 2,E3 ligase Ligand 1A |
Ligand for E3 Ligase
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(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a... |
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T7753 |
Thalidomide-O-COOH
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Cereblon ligand 3,E3 ligase Ligand 3,TCE35031 |
Others
,
Ligand for E3 Ligase
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Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTACs. |
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T13671 |
(S,R,S)-AHPC-Me hydrochloride
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VHL ligand 2 hydrochloride,E3 ligase Ligand 1 |
Others
,
Ligand for E3 Ligase
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(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cell... |
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T17877 |
VH032-cyclopropane-F
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VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101 |
Others
,
Ligand for E3 Ligase
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VH032-cyclopropane-F (Phenolic VH101) is a VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein by a linker to form PROTACs. PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4. |
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T7755 |
Thalidomide 4-fluoride
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E3 ligase Ligand 4 |
IRAK
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Ligand for E3 Ligase
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Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) ... |
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T22922 |
Lenalidomide hemihydrate
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TNF
,
Ligand for E3 Ligase
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Molecular Glues
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Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes. |
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T8412 |
(S,R,S)-AHPC
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VH032-NH2,MDK7526,VHL ligand 1 |
Others
,
Ligand for E3 Ligase
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(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. |
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T1642 |
Lenalidomide
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CC-5013 |
Apoptosis
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TNF
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Ligand for E3 Ligase
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Molecular Glues
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Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines. |
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T17927 |
(S,R,S)-AHPC TFA
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VH032-NH2 TFA,VHL ligand 1 TFA |
Others
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Ligand for E3 Ligase
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(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to crea... |
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T4207 |
(S,R,S)-AHPC hydrochloride
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VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride |
Others
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Ligand for E3 Ligase
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(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). |
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T9381 |
Thalidomide 5-fluoride
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H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro- |
Ligand for E3 Ligase
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Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) is a thalidomide-based Cereblon ligand that binds to the IRAK4 protein ligand via a linker to form PROTACIRAK4 degrader-1. |
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T77912 |
Tz-Thalidomide
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Epigenetic Reader Domain
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Tz-Thalidomide is a tetrazine-modified Thalidomide (E3 ligase ligand) with some affinity for BRD4. |
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T18816 |
Thalidomide-O-amido-C6-NH2 hydrochloride
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Others
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E3 Ligase Ligand-Linker Conjugate
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Thalidomide-O-amido-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, integrating a Thalidomide-based cereblon ligand with a linker, suitable for PROTAC synthesis. |
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T17881 |
(S,R,S)-AHPC-C10-NH2
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VH032-C10-NH2 |
Others
,
Ligand for E3 Ligase
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(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate, comprising the (S,R,S)-AHPC-based VHL ligand and a linker, designed for BET-targeted PROTAC applications. |
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T17870 |
CIAP1 ligand 1
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E3 ligase Ligand 12 |
Others
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cIAP1 ligand 1 (E3 ligase Ligand 12) is an apoptotic protein ligand based on the LCL161 derivative that recruits IAP ubiquitin ligases to degrade target proteins, and can be used to couple with androgen receptor ligands ... |
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T40019 |
Thalidomide-5-NH2-CH2-COOH
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Others
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Thalidomide-5-NH2-CH2-COOH (compound 114) is a selective inhibitor of the protomyosin receptor kinase. It is a ligand for E3 ligase and has potential for studying one or more diseases. |
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T18819 |
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
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Others
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Ligand for E3 Ligase
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Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker. Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride can be used as an immunomodulator for the treatment of cancer. |
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T18066 |
Lenalidomide-OH
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Ligand for E3 Ligase
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Lenalidomide-OH is a ligand of cereblon (CRBN), serving as an analog to Lenalidomide for E3 ubiquitin ligase. It is utilized in the recruitment of CRBN protein. Additionally, Lenalidomide-OH can be conjugated to a protei... |
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T18064 |
Lenalidomide-Br
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Ligand for E3 Ligase
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Lenalidomide-Br (Compound 41) is a derivative of Lenalidomide, which serves as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound, Lenalidomide-Br, can be conjugated to a... |
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T17350 |
ACBI1
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Apoptosis
,
Epigenetic Reader Domain
,
PROTACs
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ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in ... |
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T41224 |
CG 428
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Trk receptor
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CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidom... |
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T17871 |
E3 ligase Ligand 13
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Others
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E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degrad... |
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T35479 |
CRBN-6-5-5-VHL
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Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable.
... |
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T17868 |
E3 ligase Ligand 10
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Others
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E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated d... |
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T17364 |
AhR Ligand-Linker Conjugates 1
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E3 Ligase Ligand-Linker Conjugates 57 |
Others
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AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be ... |
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T17880 |
E3 ligase Ligand 9
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Others
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E3 ligase Ligand 9 is a compound that serves as a ligand for E3 ubiquitin ligase. It can be linked to the protein ligand through a linker, forming PROTACs or SNIPERs. These PROTACs are known to induce the degradation of ... |
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T17897 |
CIAP1 Ligand-Linker Conjugates 13
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E3 ligase Ligand-Linker Conjugates 43 |
Others
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cIAP1 Ligand-Linker Conjugates 13, containing an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker, are utilized in the development of SNIPERs[1]. |
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T39378 |
Thalidomide-O-C10-NH2
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Thalidomide-O-C10-NH2 |
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Thalidomide-O-C10-NH2 is a synthetic E3 ligase ligand-linker conjugate combining a cereblon ligand derived from Thalidomide with a linker crucial for PROTAC technology. |
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T17899 |
CIAP1 Ligand-Linker Conjugates 9
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E3 ligase Ligand-Linker Conjugates 45 |
Others
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cIAP1 Ligand-Linker Conjugates 9 feature an IAP ligand specifically targeting the E3 ubiquitin ligase, along with a PROTAC linker. It is valuable tools for developing SNIPERs[1]. |
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T18826 |
Thalidomide-O-PEG2-propargyl
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E3 ligase Ligand-Linker Conjugates 32 |
Others
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Thalidomide-O-PEG2-propargyl (E3 Ligase Ligand-Linker Conjugates 32) is a chemical compound that has been synthesized as a conjugate of an E3 ligase ligand and a linker. It incorporates the cereblon ligand based on Thali... |
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T39375 |
Thalidomide-O-amido-PEG2-C2-NH2
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Cereblon Ligand-Linker Conjugates 10,E3LigaseLigand-LinkerConjugates24,Thalidomide-O-amido-PEG2-C2-NH2 |
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Thalidomide-O-amido-PEG2-C2-NH2, which combines an E3 ligase ligand with a linker, serves as an immunomodulator for cancer treatment. |
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T17900 |
CIAP1 Ligand-Linker Conjugates 8
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E3 ligase Ligand-Linker Conjugates 46 |
Others
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cIAP1 Ligand-Linker Conjugates 8 comprises an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is specifically utilized for the purpose of SNIPER design[1]. |
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T39701 |
Pomalidomide-C7-COOH
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Pomalidomide-C7-COOH |
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Pomalidomide-C7-COOH is a chemically synthesized E3 ligase cereblon ligand-linker conjugate, utilized as an intermediate compound for the synthesis of PROTAC BCL-XL degraders. |
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T17230 |
VH032-PEG3-acetylene
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Others
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VH032-PEG3-acetylene is a synthesized conjugate compound consisting of a VH032-based VHL ligand and a linker, designed for use in PROTAC technology as an E3 ligase ligand-linker conjugate[1]. |
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T17898 |
CIAP1 Ligand-Linker Conjugates 7
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E3 ligase Ligand-Linker Conjugates 44 |
Others
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cIAP1 Ligand-Linker Conjugates 7 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. It is utilized in the design of SNIPERs[1]. |
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T18812 |
Thalidomide-PEG2-C2-NH2 TFA
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Thalidomide-NH-PEG2-C2-NH2 TFA |
Others
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Thalidomide-O-amido-PEG3-C2-NH2 TFA, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon ligand based on Thalidomide and a 2-unit PEG linker for use in PROTAC technology[1]. |
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T18673 |
(S,R,S)-AHPC-O-Ph-PEG1-NH2
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VH032-O-Ph-PEG1-NH2 |
Others
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(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) serves as an E3 ligase ligand-linker conjugate, integrating a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is utilized in PROTAC EED degrader-... |
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T39736 |
(S,R,S)-AHPC-C2-NH2
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(S,R,S)-AHPC-C2-NH2 |
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(S,R,S)-AHPC-C2-NH2 is a synthesized conjugate combining the VH032-based VHL ligand with a linker for PROTAC technology, serving as an E3 ligase ligand-linker. |
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T17888 |
CIAP1 Ligand-Linker Conjugates 6 hydrochloride
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E3 ligase Ligand-Linker Conjugates 35 hydrochloride |
Others
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cIAP1 Ligand-Linker Conjugates 6 hydrochloride is a compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized for the purpose of designing SNIPERs[1]. |
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T39876 |
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride
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Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride |
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Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride consists of a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker, making it suitable for PROTACs design. |
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T17905 |
(S,R,S)-AHPC-PEG1-OTs
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VH032-PEG1-OTs,VHL Ligand-Linker Conjugates 2,E3 ligase Ligand-Linker Conjugates 51 |
Others
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(S,R,S)-AHPC-PEG1-OTs is a chemically synthesized conjugate, functioning as an ligase ligand-linker for E3 ligase. It incorporates the VHL ligand derived from (S,R,S)-AHPC and a 1-unit PEG linker. This synthesized compou... |
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T17886 |
CIAP1 Ligand-Linker Conjugates 15 hydrochloride
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E3 ligase Ligand-Linker Conjugates 34 hydrochloride |
Others
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cIAP1 Ligand-Linker Conjugates 15 hydrochloride is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is useful in the development of SNIPERs[1]. |
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T39873 |
(S,R,S)-AHPC-C8-NH2
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VH032-C8-NH2,(S,R,S)-AHPC-C8-NH2 |
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(S, R, S)-AHPC-C8-NH2 (VH032-C8-NH2) is an E3 ligase ligand-linker conjugate. This compound comprises the VH032-based VHL ligand and a linker, specifically designed for AKT PROTAC degrader applications. |
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T18067 |
Lenalidomide-PEG1-azide
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Others
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Lenalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate that incorporates the cereblon ligand based on Lenalidomide and a linker. It is designed for use in the development of PROTAC BRD4 Degrader-2[1]. |
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T18665 |
(S,R,S)-AHPC-C4-NH2 dihydrochloride
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VH032-C4-NH2 dihydrochloride |
Others
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(S,R,S)-AHPC-C4-NH2 dihydrochloride is a chemically derived E3 ligase ligand-linker conjugate, consisting of the (S,R,S)-AHPC VHL ligand and a linker specifically designed for EED-Targeted PROTAC[1]. |
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T17891 |
CIAP1 Ligand-Linker Conjugates 2
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E3 ligase Ligand-Linker Conjugates 37 |
Others
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cIAP1 Ligand-Linker Conjugates 2 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. This compound is particularly useful in the design of SNIPERs [1]. |
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T17908 |
VHL Ligand-Linker Conjugates 15
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E3 Ligase Ligand-Linker Conjugates 56 |
Others
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VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1]. |
